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Furthermore, cardiovascular benefits were inferred from surrogate measures such as a reduction in HBA1C and BP rather than primary outcomes, which makes any clinical benefit more uncertain

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Understanding their history, mechanism, and expanding lineup empowers clinicians and patients to select the right agent, personalize dosing, and anticipate whats next in this fast-moving field.

doi: 10.1038/s41589-019-0408-1 149 WortmannMSchneiderMPircherJHellfritschJAichlerMVegiNet al

Carnitine deficiencies are also found in patients undergoing hemodialysis or those affected by any one of various organic acidemias/acidurias (e.g